Carol and I have done 5 of the 10:
Big Sur, California
Blue Ridge Parkway, North Carolina and Virginia
Million Dollar Highway, Colorado--many times as well, used to vacation in Colorado, fishing, hiking, and yes ski trips were awesome!
Red Rock Scenic Byway, Arizona--raised the kids in Arizona, did these many times, the best at sunrise and sunset!
Seward Highway, Alaska--If you go to Alaska, breathtaking to say the least. A lot of hiking and donkey paths, there are not many highways in Alaska.